Effect of Metamizole (Dipyrone) on Blood and Histological Pictures of Liver and Spleen in Rats

Kh. Hameed, B.; M. Fadhil, R.; Sh. Hussain, Rasha; A. Abdullah, Buthina; A. Hadi, Kh.; S. Obid, Wassan; H. Hadree, D.; A. Gabori, Enaam; E. Mustafa, Nadya

doi:10.21608/ejvs.2020.19551.1126

Effect of Metamizole (Dipyrone) on Blood and Histological Pictures of Liver and Spleen in Rats

Document Type : Original Article

Authors

¹ Department of Anatomy and Histology, Veterinary Medicine faculty, Tikrit University, Tikrit, Iraq.

² Department of Physiology, Pharmacology and Biochemistry, Veterinary Medicine faculty, Tikrit University, Tikrit, Iraq.

³ Department of Biology, Faculty of Education for Pure Science, Tikrit University, Tikrit, Iraq.

⁴ Department of Medical Laboratory Technique, Al-noor University College, Mosul, Iraq.

⁵ General Directorate for Education of Kirkuk, Ministry of education, Iraq.

10.21608/ejvs.2020.19551.1126

Abstract

We used in our study Twenty rats ,divided into two groups .the first group consist of 10 rats considered as a control group, while the second group treated with 0.05 ml\body weight\day of dipyron injected for 30 days duration. The toxic effect of dipyrone was obvious in the different tissue and haematotoxic effects . The histological changes were obvious in the hepatic cell whichof liver were characterized by atrophy ,irregular hepatic cells ,RBC cells in the blood sinusoid. However,the spleen tissue contains nodule (white pulpe ).The bony tissue have osteocytes large bony vacuoles and the blood vessel were congested.

Keywords