The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

Document Type : Original Article


1 3Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

2 3Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq


Human and animal anovulation is a result of polysystolic ovary PCOS which involves endocrine, reproductive, and metabolic abnormalities. Finding new medications with least amount of toxicity is a major scientific challenge. The study’s goal is to assess biochemical variables in blood serum and heart tissue in female rats as models with androgen-induced PCOS and the impact of oxidative stress in development of cardiovascular characteristics resulting from PCOS. PCOS-induced rats were treated with liquorice root [L.], green tea [GT], and marjoram [M.] extracts at 150, 250 and 100 mg Kg−1 B.W. respectively. Metformin [Met.]  20 mg kg−1 B.W. used as a standard medication. The study employed 36 female rats aged 8-10 weeks. Six [n=6] groups of rats were formed. At zero time and at the end of the trial, blood was obtained from all rats to estimate total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, glucose, total protein, CRP, glutathione, malondialdehyde, glutathione peroxidase, AST, ALT, ALP, testosterone, estradiol, progesterone in blood and CK, LDH, IL-1β and TNF-α in heart tissue. In female rats treated with androgen, there has been a rise in all measured parameters except HDL-C, estradiol, progesterone, GSH, GSH-Px and, which increased again in three extracts-treated groups. M. extract was more active than GT and L. extracts in improvement of cardiovascular [CV] parameters. Since CK, LDH and IL-1β were regained normal values. In conclusion, study demonstrated that M., GT, and L. can decrease the negative effects of PCOS in particular on cardiovascular features, and treating PCOS with these herbs is recommended.


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