Treatment of Experimental Candidiasis in Broilers with Griseofulvin

Hussein, Mohammed Ali; Ibrahim, Zaid Yaseen; Ali, Rafid K

doi:10.21608/ejvs.2024.259232.1753

Treatment of Experimental Candidiasis in Broilers with Griseofulvin

Document Type : Original Article

Authors

¹ College of Vet. Medicine

² College of Vet. Medicine, University of Fallujah

³ College of Vet. Med.

10.21608/ejvs.2024.259232.1753

Abstract

Candidiasis is a mycotic disease of avian hosts. Some species of the genus candida are the etiological agents of candidiasis. Griseofulvin is an antifungal metabolic byproduct of some fungi especially those belong to the phylum Ascomycota. Due to the shortage of research regarding this drug use in birds, this study was conducted. A number of 60 broiler chicks of 10 days old was divided in to 3 groups, 20 chicks each. Group one (G1), control group, did not receive infection nor treatment. Group two (G2), infection group, was challenged with candida albicans. Group three (G3), treatment group was infected similar to G2 then treated with griseofulvin. At 20 days of age, a sample of 5 birds from each group were necropsied to document gross lesions and collect tissue samples for histopathology. Results show that crops from infected birds in G2 have thickened wall and the lumen were lined with diphtheritic material while crops from birds that received treatment with griseofulvin showed significantly milder lesions compared to G2. Histopathological sections from infected birds of G2 were showing inflammatory cell infiltration and sloughing of the superficial epithelial layer and fungal hyphae penetrating the crop mucosa. On the other hand, histopathological sections of crops from G3 were less affected by the infection. There was very few tissues reaction and mycelial growth was only superficially penetrating the epithelium. From the finding of the present study, it can be concluded that griseofulvin is effective for the treatment of candidiasis.

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