Antihyperglycemic Effect of Aqueous Extract of Urtica dioica L. Leaves Growing in Kurdistan Region-Iraq

Omar, Ghariba A.; Mohammed, Lina Y

doi:10.21608/ejvs.2023.240984.1633

Antihyperglycemic Effect of Aqueous Extract of Urtica dioica L. Leaves Growing in Kurdistan Region-Iraq

Document Type : Original Article

Authors

Ghariba A. Omar ¹
Lina Y Mohammed ²

¹ department of chemistry, faculty of science- university of zakho

² Department of Biomedical Science, College of Medicine, University of Zakho, Zakho, Kurdistan Region, Iraq

10.21608/ejvs.2023.240984.1633

Abstract

The
primary aim of this investigation is to assess the effect on diabetes of U. dioica L. in rats with diabetes induced by alloxan. Male albino rats were assigned randomly to 3 groups: normal control rats; diabetic rats administered 500 mg/kg BW of U. dioica aqueous extract for 30 days, and diabetic rats induced by intraperitoneal alloxan injection (110 mg/ kg b. w). Serum fasting blood glucose level, lipid profile, liver and kidney parameters as well as body weight (BW) and relative weight of kidney, heart and liver were determined.
The findings of this research conducted that when a diabetic group received 500 mg/kg BW of U. dioica leaves water extract., their BW and relative kidney to BW both increased significantly (P < 0.05), while their serum fasting glucose level (FBG) decreased significantly (p < 0.0001). Moreover, the extract had no statistically significant effects on triglycerides (TG), very low-density lipoprotein (VLDL), or high-density lipoprotein (HDL) at (P > 0.05) in comparison to diabetic rats’ group, but significantly decreased serum cholesterol (TC) and low-density lipoprotein (LDL) at (P < 0.05). Concentrations of S.GOT, S.GPT, and S. urea rose before returning to normal. Our results showed that water extract of U. dioica L. made improvements to hyperglycemia, hyperlipidemia, liver enzymes, and renal function.

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