Employment of Bionanomaterials for Injured and Burned Skin Treatment in Rabbit

Hameed, Ekhlas Majeed; Mohammed, Asmaa Hadi

doi:10.21608/ejvs.2023.151597.1380

Employment of Bionanomaterials for Injured and Burned Skin Treatment in Rabbit

Document Type : Original Article

Authors

¹ 1Branch of Physiology and Medical Physics, College of Medicine, Wasit University, Wasit, Iraq

² Department of Physics, College of Science, Alnahrain University, Baghdad, Iraq

10.21608/ejvs.2023.151597.1380

Abstract

In this work, silver nanoparticles were prepared using easy chemical techniques and cheap local materials from industrial sources (silver nitrate) and natural (green apple) for comparison in terms of toxicity. Using X-ray diffraction machine (XRD) and electron microscopy (SEM) and sample element chemical analysis (EDXS), the characteristics of silver nanoparticles in terms of structural characteristics were explored. The sample bonds were tested using FTIR to obtain the highest circumstances for using silver in the therapy of burning rabbit skin. X-ray diffraction results showed the purity of the chemically prepared material (silver nanoparticles) based on the American ASTM card with Miller coefficients determined at (111, 200, 220 and 311). The silver nanoparticle diameter was measured and found between (5-21 nm), the electronic scanner result showed sample surface homogeneity and silver nanoparticles "spherical shape". It has also been studied the biological properties of silver nanoparticles. For the following bacteria (Micrococcus, Bacillus, Pseudomonas, Staphylococcus aureus and E. coli aeruginosa), silver was identified as an antibacterial agent. Silver demonstrated strong antimicrobial activity and each bacterium's inhibition diameter (30, 36, 28, 24 and 25 mm), respectively. Silver nanoparticles have been assessed toxicity to determine the best dosage for particle use as a treatment for rabbit skin burns. Approximately one year old, male, 1.5-2 kg domestic rabbits were prepared for a week prior to the experiment in a safe follow-up environment. Ultimately, the study included a full histological analysis of the treatment stages of each method used to treat rabbit skin burns (silver nanoparticles, silver-animal fat-zinc juicer) at different treatment times to determine the best model used in burn care.

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