Vancomycin-Resistant Staphylococcus aureus Causing Ocular Infections in El-Gharbia Governorate, Egypt

Document Type : Original Article


1 Bacteriology, Mycology and Immunology Department, Faculty of Veterinary medicine, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt.

2 Department of Botany and Microbiology, Faculty of Science, Kafrelsheikh University, Egypt

3 Hydrobiology Department, Veterinary Research Division, National Research Centre, El Buhouth St., Dokki, 12311 Cairo (Egypt)


Ocular infections caused by bacteria and their complications represent an important public health problem worldwide. The study was conducted to determine the antimicrobial resistance pattern and the emergence of cefoxitin- and vancomycin-resistant S. aureus causing ocular infections at El-Gharbia governorate hospitals. We collected 300 S. aureus causing ocular isolates from patients suffering from eye infections from four hospitals at El-Gharbia governorate, and the isolates were molecularly characterized using 23s rRNA PCR. Antibiotic sensitivity tests were performed using the disk diffusion test. A total of 90 (31%) S. aureus ocular isolates were identified, and distributed within the four hospitals as 25%, 33%, 48%, and 16% from Quotour hospital, El–Menshawy, El-Ramad and Quotour clinic, respectively. Moreover, S. aureus was isolated with 30.8 % and 31 % male and female patients. S. aureus ocular isolates were sensitive to ciprofloxacin, levofloxacin, cefuroxime, amikacin, azithromycin, norfloxacin, sulbactam/ampicillin and cefotaxime. In contrast, 89%, 90%, 100% and 85% of these isolates showed resistance to ampicillin, cefoxitin, doxycycline hydrochloride, and vancomycin. Whereas, the rest of S. aureus strains were cefoxitin- and vancomycin-intermediate resistant. This study alerts the emergence of cefoxitin- and vancomycin-resistant S. aureus causing ocular infections among hospitals in the El-Gharbia governorate. Additionally, ciprofloxacin is the most effective antibiotic against S. aureus causing ocular infections reported in this study.


Main Subjects

Volume 54, Issue 7 - Serial Number 7
The Scientific Conference of Kafr Elsheikh University (One World.......One Health, 5th– 8th October 2022)
November and December 2023
Pages 77-85
  • Receive Date: 20 August 2023
  • Revise Date: 11 September 2023
  • Accept Date: 20 October 2023