Effects of Oral Administration of Omeprazole and Quercetin on Inflammatory and Histopathological Alterations of Ketoprofen in Rats

Ibrahim, Hosny; Afifi, Esraa Bahgat Shehata; Galal, Azza A.A.; Metwally, Mohamed M.M.

doi:10.21608/ejvs.2025.405729.2976

Effects of Oral Administration of Omeprazole and Quercetin on Inflammatory and Histopathological Alterations of Ketoprofen in Rats

Document Type : Original Article

Authors

¹ Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt

² Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Egypt

10.21608/ejvs.2025.405729.2976

Abstract

Ketoprofen (KP) is a nonsteroidal anti-inflammatory drug (NSAID) that treats musculoskeletal injuries, osteoarthritis, and acute gouty arthritis. However, its use has been linked to certain detrimental effects on stomach, liver, and renal function. This study looked into how omeprazole and quercetin could help rats overcome the negative effects of KP. For this aim, 32 male rats were divided equally into four groups: Group I consisted of negative control rats. Rats were treated with ketoprofen in Group II (50 mg/kg b. wt.), omeprazole in Group III (20 mg/kg b. wt.), and quercetin in Group IV (50 mg/kg b. wt.). The study assessed TNF-α and IL-10 levels, as well as histological alterations in the stomach, liver, and kidney. Omeprazole plus quercetin treatment significantly (P< 0.05) reduced TNF-α and IL-10 production in the stomach, liver, and kidneys. Omeprazole and quercetin are likely to greatly improve the histopathological changes caused by KP. As a result, during the ketoprofen treatment course in rats, it is strongly advised to take either omeprazole or quercetin, or even both together.

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