Selenium Nanoparticles Ameliorate Apoptotic Pathways and DNA Neural Damage in Deltamethrin-Treated Rats

Ragheb, Mona; Shalaby, Afaf Abdelsalam; Yaseen, Areej Ahmed; Issa, Aliaa Mahmoud

doi:10.21608/ejvs.2025.415358.3060

Selenium Nanoparticles Ameliorate Apoptotic Pathways and DNA Neural Damage in Deltamethrin-Treated Rats

Articles in Press

Document Type : Original Article

Authors

¹ Research Institute of Medical Entomology, General Organization of Teaching Hospi

² Research Institute of Medical Entomology, General Organization of Teaching Hospitals and Institutes, Cairo, Egypt

³ NHTMRI, General Organization of Teaching Hospitals and Institutes, Cairo, Egypt

⁴ Faculty of Science, Cairo University, Cairo, Egypt

10.21608/ejvs.2025.415358.3060

Abstract

Our aim is to look into selenium nanoparticles (SeNPs) potency in mitigating DNA and cellular damages that lead to cell apoptosis in brains of rats treated with deltamethrin. Four groups of adult Wister albino rats were orally adminstered for four successive weeks, a control group of corn oil feeding, other groups of SeNPs, deltamethrin and SeNPs with associated doses of deltamethrin. In SeNPs treated rats, histological studies confirmed an improvement in neural tissue architecture associated with an increase in the relative brain weight index. Also, antioxidant enzymes estimation revealed an increase in the activities of catalase, superoxide dismutase and glutathione reductase and a cut down in lipid peroxidation and nitric oxide levels. Meanwhile, Immunohistological studies indicated an increased expression of Caspase 3 in tissues treated with deltamethrin however, such expression was mitigated upon SeNPs treatment which was visually confirmed by evaluating the comet assay patterns of such cells which implied decreased DNA damages. In conclusion, deltamethrin insecticide exhibited sever toxic influences on brain tissues regarding their architecture, their cellular structures and functions which would eventually directed them to apoptotic pathways. However, SeNPs may provide protective actions that could mitigate such influences and strengthen the neural potency to encounter such neural damage.

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