Determination of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymhocyte Ratio in FIV Positive and Healthy Cats Associated with SIRS

Document Type : Original Article

Author

University of Muğla Sıtkı Koçman, Faculty of Veterinary Medicine Milas, Department of Internal Medicine, Milas, Muğla, Turkey.

Abstract

This study aimed to reveal the diagnostic role of inflammatory biomarkers of neutrophil-to-lymphocyte ratio (NLR), monocyte-lymphocyte (MLR), and platelet-to-lymphocyte ratio (PLR) in cats infected feline immunodeficiency virus (FIV) and to investigate their usability in determining systemic inflammatory response syndrome (SIRS) in these cats. The study was divided into 2 different groups as FIV-positive and healthy groups. A total of 15 healthy and 15 FIV-positive cats of different breeds and ages were served to the current study. The FIV-positive group was categorised into two subgroups: SIRS positive and SIRS negative. While the median PLR value (p = 0.756) did not significantly differ between the groups, the median NLR (p = 0.049) and MLR (p = 0.019) values of FIV (+) cats were significantly higher than those of the healthy group. The average lymphocyte (p= 0.000) and PLT (p= 0.003) values of the SIRS (+) group were significantly lower compared to the healthy group. When comparing the NLR, MLR, and PLR values of the SIRS (+), SIRS (-), and healthy groups, the SIRS (+) group's median NLR (p=0.012) and MLR (0.030) values were significantly higher than the healthy group's, but the PLR values did not significantly between the three groups (p>0.05). In conclusion, NLR and MLR were significantly higher in FIV (+) cats compared to healthy cats. Furthermore, the significant increase in both parameters among SIRS-positive cats compared to SIRS-negative ones highlights the potential usefulness of MLR in identifying cats at risk for SIRS.

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History

  • Receive Date: 21 May 2025
  • Revise Date: 04 June 2025
  • Accept Date: 06 July 2025

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