Impact of Using Spirulina Solution on Growth, Blood Biochemistry, and Redox Balance in Dogs as an Oral Supplement

Jaheen, Alaa Helal; Youssef, Fady Sayed; El-sherif, Mohamed; Ali, Mohamed; Oraby, Mohamed I

doi:10.21608/ejvs.2025.371169.2731

Impact of Using Spirulina Solution on Growth, Blood Biochemistry, and Redox Balance in Dogs as an Oral Supplement

Articles in Press

Document Type : Original Article

Authors

¹ Department of internal medicine and infectious diseases, faculty of veterinary medicine, Cairo university, Egypt.

² Department of Pharmacology, Faculty of Veterinary Medicine, Cairo university

³ Department of internal medicine, Faculty of Veterinary Medicine, Cairo University

⁴ Department of internal medicine and infectious diseases faculty of veterinary medicine Cairo university Giza Egypt

10.21608/ejvs.2025.371169.2731

Abstract

Spirulina, a blue-green microalga, has garnered attention for its potential benefits in animal health due to its rich nutrient profile, including proteins, vitamins, minerals, and antioxidants. This study explores how Spirulina Platensis (SP) can enhance animal health. It focuses on its effects on body weight, hematobiochemical characteristics, and antioxidant status in dogs after in-vitro pharmacological analysis of Spirulina cytotoxicity and efficacy. Fifteen recently recovered dogs from tick infestation with average age (3-5 months) and weight (3-4 kg) were assigned to this experimental study and given 2.5 ml of SP (4%) oral solution 15 minutes before morning feed. The experiment lasted 45 days, and each animal's body weight and blood samples were obtained on days 0, 15, 30, and 45. Hematology and serum biochemistry (lipid profile, liver enzymes, renal function, and oxidant /antioxidant state) were evaluated. HPLC analysis for the SP was performed and revealed 10 molecules of polyphenols where gallic acid was the highest predominant molecule. The results revealed that SP supplementation enhanced live body weight gain, increased WBCs, and antioxidant activity, and liver enzymes, and oxidative markers at day 15, 30, and 45 with decreased in triglycerides, and LDL-C between 15 and 45 days with non-significant decrease in cholesterol level compared to the zero days (pre-SP supplementation). The current study's data suggest that SP supplementation should be added to dogs' meals to improve growth performance, antioxidant capacity, and general health.Keywords: Meat quality, Cerium oxide NPs, Zinc oxide NPs, Epididymal sperms, Ram.

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