Document Type : Original Article
Author
animal health department, DRC
Abstract
Foreign body syndrome in sheep is a real threat. It causes several complications leading to economic loses. This work throws light on the most important clinicopathological alterations associated with foreign body syndrome in the sheep and proposes new biomarkers for its detection as well as its surgical intervention prognosis. Twenty apparently- healthy ewes were counted as the control group (CG), while the other twenty ewes endured symptoms, suggested presence of foreign body in their rumens confirmed by rumenotomy, and were considered as foreign body group (FG). Blood samples were collected before surgery, immunological and clinicopathological parameters were detected and statistically analyzed. FG compared to CG, showed a significant (P<0.05) increment in the pro-inflammatory cytokines, APPs, MMPs, free radicals, cortisol, GH, TSH, globulin, triglycerides, kidney function tests, hepatic enzymes, and a significant (P<0.05) decline anti-inflammatory cytokine, total antioxidant capacity, antioxidants, T3, T4, Insulin, Albumin, glucose, T/HDL/LDL-cholesterol, total lipids, minerals, electrolytes, trace elements. It also, displayed a significant (P<0.05) microcytic hypochromic anemia and hypoferemia with neutrophilic leukocytosis. Among the studied markers, TAC and SAA displayed the highest LR as markers for the disease diagnosis, while IL-1α, IL-6, TNF-α, and Cp had the best values for the rumenotomy prognosis. Conclusion: the combining between the supportive therapies alongside rumenotomy is important for managing ewes affected by foreign body syndrome. TAC and SAA are good indicator for foreign body syndrome in sheep, but IL-1α, IL-6, TNF-α, and Cp are better for guiding rumenotomy decisions.
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