Document Type : Original Article
Authors
1
Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
2
Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
3
Department of Food Hygiene and Control, Faculty of Veterinary Medicine, South Valley University- Qena - Egypt
4
Department of pharmacology, Faulty of veterinary medicine, Mansoura University
Abstract
Administration of veterinary medications to food-producing animals and poultry can lead to accumulation of residues in tissues that are consumed, posing potential health risks to consumers, particularly if the withdrawal period is disregarded. The research involved 95 one-day-old chicks that were properly raised, and on the 35th day (weighing between 1.9 and 2.2 kg), they were randomly assigned into four groups to evaluate the residues and withdrawal period of amoxicillin, chlortetracycline, and sulphadimidine in the liver, kidney, and muscle of broilers after their oral administration (once daily for seven consecutive days) at dosages of 25 mg/kg, 50 mg/kg, and 50 mg/kg, respectively. Specimens from the liver, kidney, breast, and thigh muscle of each group were collected on the 1st, 2nd, 3rd, 5th, 7th, and 14th days following treatment and the concentrations of each utilized drug were measured in these tissues utilizing HPLC. The findings indicated that the average residual levels of amoxicillin and chlortetracycline in the liver, kidney, breast, and thigh muscle of chickens were detectable on the 1st day after the last dose, subsequently decreasing gradually until they were not detected by the 14th day post-treatment. In contrast, the average residual levels of sulphadimidine in these tissues were still detectable until the 14th day after treatment. There is evidence to support the idea that more prudent use of antibacterials in food animals will help to preserve these important medications for use in veterinary and human medicine by reducing the selection of resistant bacteria. The national government should take the initiative to support initiatives that lessen the need for antibiotics in food animals and guarantee their responsible use. To quantify the amount of antibacterial residues in food products, more research is needed.
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