Role of Liposome as an Adjuvanted Antigen Delivery System in Enterotoxaemia Vaccine in Rabbit

Articles in Press

Document Type : Original Article

Author

veterinary serum and vaccine research ,Abassia,cairo,Egypt

Abstract

Enterotoxaemia disease in weaned rabbits has a significant impact on the  rabbit industry. Clostridium perfringens type A caused an enterotoxaemia disease accompanied by severe bloat with brownish diarrhea and high mortalities. This study aims to compare the potency of a newly formulated enterotoxaemia vaccine and that of the presently available vaccine. Two types of enterotoxaemia vaccines were prepared from a toxigenic strain of Clostridium perfringens (CP) type A namely CP/liposome vaccine and CP/aluminum hydroxide gel vaccine. One received aluminum hydroxide vaccine in 2 doses (2 ml S/C with 3 weeks interval) and the other 2 groups, CP/liposome vaccine received liposome vaccine as one-shot dose (G2) and one as a control unvaccinated group (G3). Humoral immunity was quantified using indirect enzyme-linked immunosorbent assay (ELISA) and serum neutralization test. Out of two vaccines evaluated, CP/liposome vaccine produced higher protection till 11 months without any booster dose and no vaccinal reactions observed at injection site while the aluminum hydroxide gel vaccine give protection till 6 months. So, the study concluded the synergistic role of the prepared CP/liposome adjuvanted vaccine in eliciting a higher and persistent immune response and its superiority over the currently available vaccine.

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Egyptian Journal of Veterinary Sciences

Articles in Press, Corrected Proof
Available Online from 07 May 2025

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History

  • Receive Date: 20 March 2025
  • Accept Date: 05 May 2025

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