Document Type : Original Article
Authors
1
Department of Pharmacology , Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
2
Assistant professor of pharmacology, Faulty of Veterinary medicine, Mansoura University
3
Department of Development of Animal Wealth, Faculty of veterinary medicine, Mansoura University, Mansoura, 35516, Egypt.
4
Department of pharmacology, Faulty of veterinary medicine, Mansoura University
Abstract
The liver is engaged in many biochemical pathways related to growth, immunity, biotransformation, and reproduction. The objectives of liver-protecting phytotherapy are to increase liver detoxifying capacity, improve hepatic metabolism, and hepatocyte regeneration. With an evaluation of their effects on liver gene expressions (GPX-1, IGF-1, IL-10, and TLR4) as well as the levels of GPX, SOD, GSH, and MDA in the serum of treated broilers, this paper sought to provide an in-vivo study on the potential hepatoprotective effects of green tea, rosemary, and chamomile in broilers. Eighty clinically healthy, one-day-old broiler chicks were employed. The chicks were split into four groups: The control group was fed a ration devoid of medication, while the other three groups were fed for a 45- days feed mixed with 10 gm powder/kg of green tea, rosemary, and chamomile, respectively. For hematological and serum biochemical studies, blood samples were taken on the 30th, 37th, and 45th day during medication. Additionally, liver samples were taken after cessation of treatment to be examined histopathologically and to measure the gene expressions. Broilers given green tea, rosemary, and chamomile orally showed significant increases in the gene expression of glutathione peroxidase-1 (GPx) and insulin-like growth factor-1 (IGF-1) and a significant decrease in the gene expression of interleukin -10 (IL-10) and toll-like receptor -4 (TLR4). The plants induced a significant increase in serum levels of GSH, GPX, SOD, and a non-significant decrease in serum MDA levels, and showed normal histological architectures of the livers of the control and all treated groups. It is concluded that the tested plants may exert their hepatoprotective activities due to the antioxidant and anti-inflammatory properties of their active constituents. Further research is required on the pharmacological principles of the tested plants to elucidate the future pharmaceutical development of therapeutically beneficial hepatoprotective regimens.
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