Effect of Yucca Schidigera Extract on Salmonella Enteritidis-Infected Poultry Compared with Fosfomycin Drug

Abd Elmoteleb, Azza Moustafa; Hafez, Abeer Sayed; Ahmed, Haytham Mohamed

doi:10.21608/ejvs.2024.306950.2275

Effect of Yucca Schidigera Extract on Salmonella Enteritidis-Infected Poultry Compared with Fosfomycin Drug

Articles in Press

Document Type : Original Article

Authors

¹ Senior researcher of pharmacology, Animal Health Research institute, Agriculture Research centre

² Immunology Department, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Dokki, Giza

³ 3Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Centre (ARC)Dokki, Giza12618, Egypt

10.21608/ejvs.2024.306950.2275

Abstract

The research aimed to investigate the impact of Yucca schidigera extract on Salmonella enteritidis -infected poultry compared to the fosfomycin drug. 140 salmonella free chickens were classified into first control-negative group and four Salmonella infected groups at nine days old (1×108 CFU/ml orally) orally. The second group acts as a positive group, while the 3rd, 4th, and 5th groups were treated with fosfomycin, Yucca schidigera extract, and both of them, respectively. Fosfomycin was administered at 5 days post infection at 14d old for five days. Yucca extract was administered from day one until the end of the experimental period (42d). The re-isolation of salmonella from the all treated groups after 35 days was negative. Fifth group showed normal liver function enzymes, urea and creatinine; maintain albumin and globulin at normal levels from 14 to 35 days; and keep the normal values of total antioxidants. The fourth and fifth groups displayed highly significant levels of lysozyme at 21 days old followed by a non-significant decrease at 28 and 35 days old, and decrease in relative fold changes of IL-6 compared with the second group. In the fifth group, the hemagglutination inhibition antibody titer was non-significantly higher at 21 and 28 days old, and there was a significant increase at 35 and 42 days old in comparison with the fourth group. Therefore, Yucca schidigera is a safe, effective, biocompatible, and cost-efficient alternative natural product that could be used for the treatment of salmonellosis by enhancement immune response and activated antioxidative capacity.

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