Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits

Elshazly, Amany H.M.; El-Hossary, Ghada Ghanem; Abdel-Ghaffar, Amany; Mahmoud, Atef Mohamed; Moemen, Leqaa; Elfoly, Marwa; Elgohary, Amal; Ata, Ahmed Mostafa

doi:10.21608/ejvs.2024.293173.2125

Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits

Document Type : Original Article

Authors

¹ Pharmacology Department, Research Institute of Ophthalmology, Giza, Egypt.

² Biochemistry Department, Research Institute of Ophthalmology, Giza, Egypt.

³ Ophthalmology Department, Research Institute of Ophthalmology, Giza, Egypt.

⁴ Ocular Physiology Department. Research Institute of Ophthalmology, Giza, Egypt.

10.21608/ejvs.2024.293173.2125

Abstract

One of the major limitations in ophthalmic delivery is the poor bioavailability of drugs from conventional eye drops. Pre-corneal drug loss factors include rapid tear turnover, transient residence time, and the relative impermeability of corneal epithelium. Occasionally, systemic absorption of drugs may result in systemic side effects.
To overcome these issues, controlled drug delivery systems were developed, including different types of in situ gel-forming systems based on different mechanisms (temperature, pH, or ion activated) using different polymers that have been explored for sustained ocular delivery. This study aims to formulate ocular drugs as loaded ionic and pH-activated in situ hydrogel formulas for controlled drug delivery systems aiming to increase the pre-corneal residence time and reduce the frequency of application, limit side effects, and improve patient adherence to therapy. This study will conduct biochemical and ophthalmological tests for combined lecithin, alginic acid, and chitosan-loaded prednisolone eye drops in an animal model of induced uveitis.

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