The effect of Hyoscine on serum serotonin and acetylcholine levels, and their impacts on neuro-behavior in mice

Alabdaly, Yamama Zuher; Abbas, Mayssam Muhsin

doi:10.21608/ejvs.2024.288902.2080

The effect of Hyoscine on serum serotonin and acetylcholine levels, and their impacts on neuro-behavior in mice

Document Type : Original Article

Authors

¹ Department of Physiology, Biochemistry and Pharmacology, Collage of Veterinary Medicine, University of Mosul, Mosul, Iraq

² Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq, department of

10.21608/ejvs.2024.288902.2080

Abstract

The significance of this study stems from the fact that the previously prescribed therapeutic indications for Hyoscine to prevent nausea and vomiting may be related to its effect on the nervous system in general, and memory in particular, but the exact mechanism is unknown and requires additional investigation. to study the neurobehavioral effects of Hyoscine and their relationship to serotonin and acetylcholine in mice The mice are divided into 3 groups, each group consisting of 10 animals. The first group is control, the second group is given a dose of 2 mg/kg, and the third group is given 4 mg/kg. Neurobehavioral experiments were conducted for half of the animals after two weeks had passed, the rest after 4 weeks. The LD50 of Hyoscine is 196 mg/kg when given by i.p. injection. A decrease in motor activity was recorded with doses of 2 and 4 mg/kg and increase in the number of rearing times as compared to the control group after 2 and 4 weeks of treatment. . The dose of 4 mg/kg Hyoscine detected a significant increase in serotonin levels compared to the control group. The Hyoscine 2 and 4 mg/kg groups had significantly lower acetylcholine and COMT enzyme levels than the control group. Hyoscine affects the nervous system by increase in the level of serotonin and acetylcholine and COMT enzyme in the blood of mice.

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