Proliferating cell nuclear antigen (PCNA) expression and serum IL-8 product in leiomyomas

Al-Ammiri, Hind H.

doi:10.21608/ejvs.2024.277094.1924

Proliferating cell nuclear antigen (PCNA) expression and serum IL-8 product in leiomyomas

Articles in Press

Document Type : Original Article

Author

hind H. Al-Ammiri

MICROBIOLOGY / immunology OF veterinary medicine, college of vet. medicine / university of Baghdad.

10.21608/ejvs.2024.277094.1924

Abstract

Uterine leiomyomas are the most common neoplasms of the female genital tract with medical and economic problems. The objective of this study was to investigate the effect of proliferating cell nuclear antigen (PCNA), Interleukin 8(IL-8), age and menopausal stage on Leiomyoma development. Forty eight Iraqi women were divided to 28 uterine Leiomyoma patients of whom leiomyoma tissues, adjacent myometrium and serum samples were collected from them during hysterectomy. As well, serum samples were collected from 20 apparently healthy volunteers(control). Tissue PCNA, serum IL-8 level were measured by immunohistochemistry(IHC) and ELISA technique respectively. PCNA was positive expressed in 11(39.2%) out of 28 leiomyoma tissues, while all of 20 normal myometrium were with negative expression, PCNA was unrelated to age and menopausal stage.

The mean level of serum IL-8 was elevated significantly (P<0.05) in patients (140pg/ml) compared to that of control (60 pg/ml), IL-8 seems to be increased in postmenopausal stage. In conclusion PCNA, IL-8 showed significant higher level in leiomyoma.

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