Document Type : Original Article
Authors
1
Ministry of Education, Directorate of Education in Wasit, Wasit, Iraq
2
Department of Biology, College of Science, University of Wasit, Wasit, Iraq
3
Department of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, University of Wasit, Wasit, Iraq
10.21608/ejvs.2024.284082.2022
Abstract
This study
was designed to experimentally assess the effect of formalin on lipid profile [cholesterol, lowdensity lipoprotein (LDL), high-density lipoprotein (HDL), very lowdensity lipoprotein (VLDL) and triglyceride (TG)] and the protective role of vitamin C. Totally, 24 adult male albino rats were purchased, prepared, and divided equally into 4 groups; control (drenched distilled water), EG1 (drenched 200 ppm of formalin, daily), EG2 (drenched 300 ppm of formalin, daily) and EG3 (drenched 300 ppm of formalin and 100 mg/Kg B.W orally of vitamin C, daily). Then, all study animals were subjected to direct collection of blood from the heart, and obtaining of sera. The lipid profile results of the experimentally treated group with formalin showed a significant increase in concentrations of serum cholesterol, LDL, VLDL and TG, but significant decrease was seen in the concentration of HDL. Based on our results, there is a significant association between formalin and lipid profile; therefore, accidental exposure to formalin can cause an alteration in cholesterol, LDL, VLDL, HDL and TG leading to increase the risk of acute or chronic toxicity, and then, occurrence of diseases. Our study showed that the locally and globally formalin-related studies are few and need to be supported to detect pathogenesis and mode of action for formalin toxicity. In addition, there are many materials used in the workplace can be hazardous when they come into contact with or be absorbed into the body. Hence, furthermore local studies are of great importance to provide additional data.
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