Enhancing Cutaneous Wound Healing: the Therapeutic Potential of Topical Curcumin Extract in A Rat Model

H. Mustafa, Hana; Ali, Othman Jalal; A. Abdulrahman, Hanar; M. A. Hassan, Snur; F. Salih, Lana; S. Faraj, Sara

doi:10.21608/ejvs.2024.279936.1966

Enhancing Cutaneous Wound Healing: the Therapeutic Potential of Topical Curcumin Extract in A Rat Model

Document Type : Original Article

Authors

¹ Department of Surgery and Theriogenology, College of Veterinary Medicine, University of Sulaimani, Sulaymaniyah, Iraq

² Department of Pharmacy, Kurdistan Technical Institute, Sulaymaniyah, Iraq

³ Department of Anatomy and Pathology, College of Veterinary Medicine, University of Sulaimnai, Sulaymaniyah, Iraq

10.21608/ejvs.2024.279936.1966

Abstract

This study conducted on twenty-four Wistar rats suggests that curcumin holds promise for enhancing wound healing. Through dividing the rats into control and treated groups, along with the creation of experimental excisional skin wounds on their backs, the effects of curcumin ointment were evaluated and compared to the non-treated group. The results indicated significant improvements in wound healing among the group treated with curcumin ointment compared to the control group. Specifically, the treatment group exhibited excessive angiogenesis, which refers to the outgrowth of newly formed blood vessels, the fundamental element for providing oxygen and nutrients to the newly growing tissues. The increase in the intensity of granulation tissue could indicate improved wound-bed preparation and tissue regeneration. The enhanced epidermal re-epithelialization observed in the treated group suggests expedited wound closure and tissue regeneration. These findings underscore the multifaceted effects of curcumin, including its antioxidant, antimicrobial, and anti-inflammatory properties, which likely contribute to its positive effects on wound healing. By reducing inflammation, combating oxidative-stress, and preventing microbial colonization, curcumin creates an optimal environment for efficient wound healing. Overall, the study supports the potent effects of curcumin as a medical support in wound care, highlighting its versatility as a natural treatment option for promoting wound healing and preventing complications. However, further studies and clinical investigation are recommended to and clinical trials are necessary to advocate these findings, and to optimize the accurate dosages of curcumin for wound management in human patients.

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