Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study

El Adawy, Mohamed A A. El Adawy; Abd El-Latif, Amera; Farrag, Foad; Shukry, Mustafa; Braiji, Shafiqah H Braiji H; Hanafy, Abeer

doi:10.21608/ejvs.2024.278575.1949

Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study

Document Type : Original Article

Authors

¹ Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

² Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

³ Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

⁴ East Jeddah General Hospita

10.21608/ejvs.2024.278575.1949

Abstract

The immune system, a complex network of cells and chemicals, protects the body from foreign antigens. Zingerone offers significant benefits like antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Vitamin C, a potent antioxidant, shields crucial biomolecules like proteins, lipids, and nucleic acids. against oxidative damage. Forty rats were classified into control, Zingerone, vitamin C and Zingerone + vitamin C treated groups. Hematological, biochemical, gene expression, histological and Immunohistochemical investigation were used in the evaluation of both substances on the immune system. Zingerone and Vitamin C have demonstrated potential synergistic effects on blood parameters and immune function. Their antioxidant action may enhance erythropoiesis and protect against oxidative stress, while their influence on leukocyte populations could improve immune defense and regulate inflammation as well as modulate cytokine levels and surge CD4 and CD8 positive T-lymphocytes. in conclusion These findings point to the complex interplay of dietary components in immune health and warrant further investigation for therapeutic potential.

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