Document Type : Original Article
Authors
1
Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul.Mosul, Iraq
2
physiology ,biochemistry and pharmacology /university of Mosul /Mosul /Iraq
3
College of Veterinary Medicine /University of Mosul
Abstract
The purpose of the study was to assess the toxic effects of the imidaclopri (IMI) in mice, as well as on their pups, by determining the LD50 using the Dixon method, measuring motor activity and neurobehavioral, supported by histological sections of the brains of pups. The oral LD50 dose in both males and females was 113.15 and 107.2 mg/kg respectively. The treated mice with acute doses of IMI showed signs of poisoning represented by salivation, nasal discharge, lacrimation, dyspnea, itching, lethargy, piloerection, tremor, Straub tail, and convulsion in 20 to 100% of the animals. Ranging between oral treatment of pregnant mothers with the IMI at doses of 11 and 34 mg/kg from the 7th to the 15th day of pregnancy led to defects in behavioral measurements, represented by: significant delayed growth differences in the times of pinna opening, lint growth, eye-opening in the treated groups compare to the control group. Also, there was a significant elongation in time postnatal behavior tests which included surface righting reflex and a cliff avoidance test, moreover, the other behavioral tests including the olfactory discrimination test and swimming performance test showed significant differences in lowering of scores in lowering of the sources between treated and control groups as well as histopathological changes in the pups’ brains represented by vacuolization in the cortex of the cerebrum, periaxonal edema, neuronophagia, and glial cell satellitosis around neurons, liquefactive necrosis in the cortex of cerebrum with periaxonal edema, glial cells' satellitosis of neurons, gliosis, and neuronophagia. Its concluded that IMI has toxicological effects represented by developmental and neurobehavioral defects enhanced by histological changes in mice.
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