The Testicular Toxicity Caused by 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin in \ Rats, as well as the Potential Protective Impact of Resveratrol

Document Type : Original Article


1 Pathology and Poultry Department, Veterinary Medicine College, Tikrit University, Iraq.

2 Pathology and Poultry Department, Veterinary Medicine College, Baghdad University, Iraq.


During the developmental stage, both humans and animals exhibit heightened sensitivity to exposure to harmful substances. Dioxin, being an endocrine disruptor, is recognized for its ability to affect testicular functioning and fertility. The current study sought to investigate the influence of Resveratrol (RES) on the harmful effects of 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin (TCDD) in the testicular tissue of rats. (Acute and subacute toxicity models were executed, where the experimental design was consisted of 7 groups ; G1 (control –ve), G2 vehicle ( acetone + corn oil), G3 TCDD ( 4 µg/kg b. w.), G4 TCDD ( 2 µg/kg b. w.), G5 50 microgram/kg b w (RES), G6 (TCDD ( 4 µg/kg b. w.)+ RES),G (TCDD( 4 µg/kg b. w.) + RES). The serum hormonal levels of testosterone were analyzed. The results of the current study demonstrate that the intoxication of TCDD leads to testicular injury, specifically affecting serum hormone levels and semen analysis parameters. Furthermore, assessment of the testis's microscopic features, including a histological defects due to. exposure to TCDD and the rise in apoptotic activity were detected. Furthermore, our findings unequivocally illustrate the therapeutic capacity of Res in mitigating testicular damage generated by TCDD.


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