Protective Effects of Golden Berry (Physalis peruviana L.) Juice against Diabetic Renal Injury in Rats

Document Type : Original Article


1 Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia

2 Regional center for food and feed, Agricultural research center, Giza, Egypt

3 Department of Nutrition and Food Science, Faculty of Home Economics, Helwan University, Egypt.

4 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt


The objective of this research was to estimate the kidney-protective properties of golden berry (Physalis peruviana L.) fresh juice (GBJ) in rats with streptozotocin (STZ)-induced type 1 diabetes. Thirty male rats were separated into two groups: the control (n=6) and the diabetes (n=24) groups. The diabetic rats were then subdivided into four groups (6 rats each): untreated diabetes, metformin (Met)-treated diabetic, GBJ-treated diabetic, and GBJ + Met-treated diabetic. The treatment duration lasted for eight weeks. The findings demonstrated that GBJ reduced serum glucose levels, ameliorated pancreatic degeneration in both the exocrine and endocrine glands and enhanced serum lipid profile markers. GBJ administration improved serum markers of kidney injury (creatinine and blood urea nitrogen) and mitigated the pathological features of kidney damage induced by STZ. The biochemical analysis further revealed that GBJ decreased oxidative stress levels, as evidenced by reduced malondialdehyde levels, and improved the antioxidant enzymes activity (catalase and glutathione reductase) relative to the diabetic untreated group. Additionally, GBJ improved serum levels of advanced glycation end-products (AGE). GBJ significantly enhanced the effects of Met. Our findings indicate that GBJ can mitigate STZ-induced kidney damage through its antioxidant, antihyperglycemic, and antihyperlipidemic properties. Additionally, GBJ inhibits AGE, thereby contributing to its renoprotective effect.


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