Protection of Resveratrol Against Nephrotoxicity in Rats Produced by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin

Document Type : Original Article

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pathology

Abstract

We conducted a study to examine the impact of Resveratrol (RES) on the renal tissues of Wistar rats that were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and developed kidney damage. Applied on albino male rats (102), the age range ( 8-9 ) weeks and the weight range (80 -90) gms, (32) rats were used for acute stage of toxicity, while others (70 ) rats were involved as a chronic toxicity;   the experiment design consists of 7 groups ; G1 (control –ve), G2 vehicle ( acetone + corn oil), G3 TCDD ( 4 µg/kg b. w.), G4 TCDD ( 2 µg/kg b. w.), G5 (RES), G6 (TCDD ( 4 µg/kg b. w.)+ RES),G (TCDD( 4 µg/kg b. w.) + RES). We found that malondialdehyde (MDA), urea and creatinine levels in the groups treated with TCDD showed significant increases compared to the other groups, despite a decrease in the levels of reduced glutathione (GSH) and catalase (CAT) in the TCDD groups. Comparing to the other groups, we observed a rise in GSH and CAT levels, as well as a decrease in MDA, urea, and creatinine levels in the RES treated group. The administration of RES improved the oxidative stress markers and histological alterations caused by TCDD.

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History

  • Receive Date: 19 April 2024
  • Revise Date: 04 May 2024
  • Accept Date: 08 May 2024

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