The Curing Activity of 5-Fluorouracil (5-FU) and Its Role in Reducing The Antibiotic Sensitivity in Some Resistance Bacteria

Document Type : Original Article

Authors

1 Department of Biology, College of Science, University of Mosul, Mosul, Iraq.

2 Department of Biology, College of Science, University of Mosul, Mosul, Iraq

Abstract

The results showed that all the studied bacterial isolates had multiple resistance to the studied antibiotics before treatment with (5-FU). The current study aimed to investigate the curing activity of the anti-cancer drug (5-FU) and its effect on bacterial resistance to antibiotics. the results of the current study showed variation in plasmid content between different isolates (Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli). The results showed that all of the studied isolates lost their plasmids completely after treatment with sub-MIC concentration of the drug (5-FU). However, treatment with (5-FU) resulted in the loss of resistance of all isolates to the antibiotics to which they were resistant before treatment, the antibiotics (AM,ATM,FEP) became more affecting after treatment with the drug against s.aureus and (PRL,FEP,MEM,CIP)against p.aruogenosa compared with the rest of the antibiotics studied. It was concluded in the current study that the anti-cancer drug (5-FU) demonstrated a distinct plasmid curing ability and had a strong effect on the removal of bacterial resistance to antibiotics, which opens the way for the use of this drug in combination with antibiotics as therapeutic combination against the multidrug resistant pathogenic bacteria which may require conducting additional experiments to investigate the activity of this therapeutic combination.

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History

  • Receive Date: 15 February 2024
  • Revise Date: 29 March 2024
  • Accept Date: 01 April 2024

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