Analgesic and Anti-inflammatory Effects of Montelukast in Chicks

Albadrany, Yasser; Naser, Ahmed; Mousa, Yaareb J.

doi:10.21608/ejvs.2024.266227.1810

Analgesic and Anti-inflammatory Effects of Montelukast in Chicks

Document Type : Original Article

Authors

¹ Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IRAQ

² Department of physiology, biochemistry, and pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

³ Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul-Iraq

10.21608/ejvs.2024.266227.1810

Abstract

The goal of the study was to assess the analgesic and anti-inflammatory properties of montelukast in chicks. Methods: The oral median analgesic effective dose (ED₅₀) of montelukast was determined by the up-and-down method. An electrical stimulator was used to determine the analgesia of montelukast over time. Formalin test was used to determine the analgesic and anti-inflammatory activities of montelukast. Results: oral median analgesic effective dose (ED₅₀) of montelukast was 9.23 mg/kg. Montelukast (18 and 36 mg/kg) had significant analgesic activity over time compared with a control group, and the peak of analgesia of montelukast was observed later one hour of treatment. Montelukast showed significant analgesic and anti-inflammatory activities in the formalin test, represented by a significant increase in the commencement of lifting the right foot, a decrease in the number of lifting the right foot, and significant a decrease in the thickness of the paw in comparison to control group. Conclusion: Montelukast possesses noteworthy effects of eliminating pain and inflammation in chicks.

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