Study for Evaluation of the Protective Effects of Urtica Dioica Leaves on Cardiac Function In Alloxan-Induced Diabetic Albino Rat

Bashir, Thamer Mohammed; Mohammed, Chinar Mustafa; Haji, Abdulsatar; Mohammed, Ihsan Husain

doi:10.21608/ejvs.2023.223310.1543

Study for Evaluation of the Protective Effects of Urtica Dioica Leaves on Cardiac Function In Alloxan-Induced Diabetic Albino Rat

Document Type : Original Article

Authors

¹ Dept. of Biology, Faculty of Science, University of Zakho, Kurdistan Region, Iraq

² Biology department, faculty of science, university of Zakho, Duhok, Iraq

³ Dept. of Physiology, College of Medicine, University of Duhok, Kurdistan Region, Iraq

10.21608/ejvs.2023.223310.1543

Abstract

Urtica dioica (UD) is used for a number of therapeutic purposes. Has traditionally been used in the control of cardiovascular disorders, especially hypertension. Also, the leaf extract of UD has been reported to improve glucose homeostasis in vivo. This raises the question of the relationship between UD, diabetes, and heart disorders. Therefore, this study aimed to evaluate the effect of watery leaf extract UD on the heart parameters associated with diabetes mellitus (DM) in Wistar rats. Animals were divided into 4 groups (N = 25). The untreated normal control rats only received distilled water (n = 8).), diabetic control rats group received alloxan 120 mg/Kg body weight (n = 7), the diabetic rat group treated with UD at 250 mg/kg body weight (n = 5), and the diabetic rats that received UD extract at 500 mg/Kg body weight (n = 5) orally twice daily for 5-6 days. Data showed that in the diabetic group heart rate decreased and induce bradyarrhythmia. After treating diabetic rats with 250 mg/kg enhancement in heart rate was recorded. Additionally, increasing the UD concentration to 500mg/kg further increases the heart rate to the normal value. The current study indicates widen in QRS, which seems to be disturbances of intraventricular conduction that can be seen in right and left bundle branch blocks, heart failure, and myocardial ischemia. Conclusively, these data show that UD appears to have antidiabetic and noncytotoxic properties, it is associated with reducing the effect of diabetics on the heart.

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