Impact of Baobab Consumption on Some Biochemical Alterations in Male Diabetic Rats

Salih, Dhuha Waleed; Alnajar, Husamuldeen Slim; Hussein, Dakheel

doi:10.21608/ejvs.2023.228137.1557

Impact of Baobab Consumption on Some Biochemical Alterations in Male Diabetic Rats

Document Type : Original Article

Authors

¹ College of Veterinary medicine/Tikrit university/Iraq

² Dept of pharmacology College of Medicine &ndash; Tikrit University.Salah aldeen/Iraq

³ physiology- college of veterinary medicine-Tikrit university

10.21608/ejvs.2023.228137.1557

Abstract

Diabetes is a chronic metabolic, which contributes to disease progression and complications. Baobab is a tropical fruit tree known for its medicinal properties and rich content of antioxidants and anti-inflammatory compounds. This research aimed to investigate the potential anti-inflammatory effects of baobab (Adansonia digitata) in an induced diabetic rat. The study utilized an interventional design and divided the rats into various treatment groups, including a control group, diabetic group, and groups treated with baobab extract, metformin, or a combination of both. Blood samples were collected at various time points to evaluate blood sugar levels, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels. The results showed that baobab and metformin, either alone or in combination, significantly reduced blood sugar levels compared to the positive control group. Additionally, baobab demonstrated a potential for reducing TNF-α, IL-6, and IL-10 levels, indicating its anti-inflammatory effects in the diabetic model. These findings suggest that baobab may have therapeutic implications in managing inflammation associated with diabetes. However, further research is required to fully elucidate the underlying mechanisms and evaluate the clinical effectiveness of baobab in human subject.

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