Association of D-Dimer-Fibrinogen Ratio, Platelet-Lymphocyte Ratio, and Vitamin D Levels with Pneumonia in Calves: Insights into Inflammation and Coagulation Mechanisms

Manulboga, Mutlu; Tendar, İlayda; &Ouml;zalp, Tahir; Erdogan, Song&uuml;l; Ural, Kerem; Erdogan, Hasan

doi:10.21608/ejvs.2023.220753.1535

Association of D-Dimer-Fibrinogen Ratio, Platelet-Lymphocyte Ratio, and Vitamin D Levels with Pneumonia in Calves: Insights into Inflammation and Coagulation Mechanisms

Document Type : Original Article

Authors

¹ Aydın Adnan Menderes University, Faculty of Veterinary Medicine, Department of Internal Medicine

² Department of Internal Medicine, Faculty of Veterinary Medicine, Aydın Adnan Menderes University

10.21608/ejvs.2023.220753.1535

Abstract

The objective of the proposed study was to establish a correlation between the levels of D-dimer-fibrinogen ratio, platelet-lymphocyte ratio, and vitamin D in patients with calf pneumonia. Three groups were established for this purpose. Group I consisted of healthy controls (n=7), while Group II (n=7) and Group III (n=7) were comprised of animals with pneumonia who received different treatments. Hemogram, coagulation parameters, and vitamin D levels were measured in all three groups of animals. Additionally, the platelet-lymphocyte ratio (PLR) and D-dimer-fibrinogen ratio (DFR) were calculated and subsequently analyzed. The DFR measurements on Day 0 for calves with pneumonia exhibited a notable difference compared to those of the healthy group. Meanwhile, the Day 0 vitamin D measurements in healthy calves were significantly lower from those in calves with pneumonia. However, there was no significant difference observed in the PLR levels between healthy calves and calves with pneumonia who received treatment. The study's results suggest that the levels of vitamin D have an effect on the inflammatory process and coagulation parameters in calves with pneumonia.

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