Spectrophotometric Method for Determination of Nifedipine in Pure Form and its Pharmaceutical Preparation

Document Type : Original Article

Authors

Department of Chemistry, Education College for Girls, University of Mosul, Iraq.

Abstract

For nifedipine (NIF) determination in both its pure Form and in pharmaceutical dosage forms, a straightforward, quick, exact, and sensitive analytical method has been devised. To complete the reaction and obtain a colorful product bound to the amount of NIF, this approach uses a proton transfer between the NIF and 3-5 dinitro salicylic acid (DNSA) reagents in a basic medium while standing. This product's highest absorption wavelength is 359 nm. Over a concentration range of 1.5-12.5 ppm, a linear calibration curve with a correlation coefficient of 0.9991 was observed. The molar absorptivity was 4.522 × 104 L.mol-1.cm-1, and Sandell's sensitivity index was equal to 0.010 μg.cm-2. The limit of detection (LOD) and quantification (LOQ) values are 0.359 and 1.121 ppm, respectively. The suggested approach method was applied to estimate the NIF in the available pharmaceutical preparations (tablets). The results confirmed that the Method is successful by studying the recovery using the standard addition method.

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History

  • Receive Date: 23 March 2023
  • Revise Date: 22 April 2023
  • Accept Date: 05 May 2023

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