The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.

Elgharib, Inas M.; Abdelhamid, Fatma M.; E. Elshopakey, Gehad; Fawzy, Mohamed; Risha, Engy F.

doi:10.21608/ejvs.2023.181316.1417

The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.

Document Type : Original Article

Authors

¹ Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.

² Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt

10.21608/ejvs.2023.181316.1417

Abstract

The current investigation's objective was to ascertain whether vitamin C has a safe-guarding impact in opposition to the harmful effects of cadmium, a heavy metal with a high toxicity and a substantial environmental pollutant. The experimental group consisted of 20 rats divided into 4 groups. The current study was carried out for 30 days. A (control) , B ( cadmium group) 15 mg\kg CdCl2) , (vitamin C group) ( 150 mg\kg vitamin C) , D (CdCl2 15 mg/kg +150 mg/kg b.wt) orally. After 4 weeks blood samples were taken and liver tissues. Findings revealed a substantial drop in RBC count, Hb concentration, and PCV (< P 0.05) and a substantial rise in WBC count (< P 0.05). On another hand, findings also revealed a substantial drop in total protein, albumin and an increase concentration of globulin, total and direct bilirubin. Also increase concentrations of ALP , AST and ALT . In addition to antioxidants GST, GSH, CAT, SOD, rise in MDA of cadmium group in comparison to A group but, when vitamin C combined by cadmium chloride, the results indicated a noticeable improvement in the parameters under study, indicating the therapeutic effect of vitamin C against cadmium chlorides toxicity in rats.

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