L-carnitine Improves Atherosclerotic Plaques in Hyperlipidemic Animal Model (Hyperlipidemic Rabbits)

Zarei, Leila; Farhad, Negin; Abbasi, Ata; Naji Haddadi, Siamak

doi:10.21608/ejvs.2022.133398.1338

L-carnitine Improves Atherosclerotic Plaques in Hyperlipidemic Animal Model (Hyperlipidemic Rabbits)

Document Type : Original Article

Authors

¹ Faculty of Medicine, Department of Anatomical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran

² Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.

³ Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

10.21608/ejvs.2022.133398.1338

Abstract

Use of L-carnitine (L-c.) bears potentials of decreasing hyperlipidemia following fat diet feeding. 25 Animal (rabbits) were divided randomly into five groups . Normal group were kept on a plain chow diet for 75 days. HC classes were on a diet (hypercholesterolemic diet) for seventy-five days. Atorvastatin group were fed the same diet and received atorvastatin orally (20mg/kg/day) from day forty-five for thirty days. L-carnitine group were fed the same diet and intraperitoneal L-c. (250 mg/kg/day). Treatment group were fed the same diet and atorvastatin orally (l0 mg/kg/day) and L-carnitine intraperitoneally (125 mg/kg/day). Histology of aorta and biochemistry of serum were carried out. Foam cells with interrupted endothelial lining and transformed muscle fibers were observed in aorta wall in hypercholesterolaemic rabbits. Normal aorta wall was observed in rabbits of Atrovastatin and treatment groups. In rabbits of HC group triglyceride was significantly increased compared to that of other groups (P<0.05). The animals that received L-carnitine showed significantly reduced triglyceride (P<0.05). L-Carnitine reduces atherosclerotic plaques.

Keywords