Evaluation of the Antipyretic, Analgesic, and Anti-inflammatory Effects of Pregabalin in Chicks

Bashar, Qutaiba M.; Albadrany, Yasser M.

doi:10.21608/ejvs.2022.131986.1336

Evaluation of the Antipyretic, Analgesic, and Anti-inflammatory Effects of Pregabalin in Chicks

Document Type : Original Article

Authors

¹ University of Mosul, College of veterinary Medicine, Department of Physiology Biochemistry and Pharmacology, Mosul, Iraq.

² Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IRAQ

10.21608/ejvs.2022.131986.1336

Abstract

Background: Pregabalin is an anticonvulsant medication. It’s been utilized as an analgesic in animals to treat neuropathic pain that doesn’t respond to NSAIDs or opiates.
Objective: This study aimed to investigate the potential antipyretic, analgesic, and anti-inflammatory effects of pregabalin in chicks as a model.
Methods: A randomized controlled study was conducted on sixty-two clinically healthy Ross chicks aged seven days. The antipyretic effect of pregabalin was determined using Baker’s yeast test and anti-inflammatory effect was determined using the formalin test.
Results: Pregabalin reduced the temperature throughout the experimental period compared with that in the group treated with Baker’s yeast. In the formalin test, pregabalin induced an analgesic effect against pain induced by formalin injection into the plantar region of the chick foot. This was shown by a significant increase in the onset of raising the right foot and a significant decrease in the number of the right foot raises compared with the control value. A substantial decrease in the thickness of the right foot compared to the control value was observed in the anti-inflammatory activity of pregabalin in comparison to the control group.
Conclusion: Pregabalin has an antipyretic effect which was recorded for the first time. Also it has a substantial analgesic and anti-inflammatory activity.

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