The protective role of Vit.B12 on neurotoxic effect of diazinon has been studied and conducted on 24 adults male wistar rats were divided equally into 4 groups, the group I was used as normal control; group II was orally given 1/10 LD50 (3.8mg/kg.bw) of diazinon for one month; group III was orally given 1/10 LD50 (3.8mg/kg.bw) of diazinon plus systemic injection (I.M route) of Vit.B12 (4 mg/kg.bw) for one month; group IV was given systemic injection (I.M route) of Vit.B12 (4 mg/kg.bw) only for one month. Biochemically it revealed a significant (P≤0.05) increase in GSH, CAT and SOD values in both Vit.B12 groups (group III and group IV) as well to control group when compared to diazinon group (group II); while the values of MDA and peroxynitrite revealed a significant (P≤0.05) decreases in the both Vit.B12 groups (group III and group IV) as well to control group when compared to diazinon group (group II); moreover, the histopathological results of the diazinon group (group II) revealed a serious neurologic changes included necrotized neurons, diffuse neuronal edema, perivascular edema and hyperplasia of glial cells; while the Vit.B12 groups showed no effective histopathological changes were more or less to control group. There are a little information has been provided concerning the relation between diazinon and Vit.B12,therefore, the current study concluded that the Vit.B12 has a significant protective role against the neurological toxic effects of diazinon on basis of histopathological and biochemical patterns.
Hameed, A., & Ahmed, J. (2021). The Neuro-protective Role of Vitamin B12 in Diazinon Poisoned Male Wistar Rats: Histopathological and Biochemical Evaluation. Egyptian Journal of Veterinary Sciences, 52(Issue The 9th International Conference of Veterinary Research Division National Research Centre, Giza, Egypt 27th -29th September 2021), 35-40. doi: 10.21608/ejvs.2021.90194.1264
MLA
Aseel Kamil Hameed; Jihad abdulameer Ahmed. "The Neuro-protective Role of Vitamin B12 in Diazinon Poisoned Male Wistar Rats: Histopathological and Biochemical Evaluation", Egyptian Journal of Veterinary Sciences, 52, Issue The 9th International Conference of Veterinary Research Division National Research Centre, Giza, Egypt 27th -29th September 2021, 2021, 35-40. doi: 10.21608/ejvs.2021.90194.1264
HARVARD
Hameed, A., Ahmed, J. (2021). 'The Neuro-protective Role of Vitamin B12 in Diazinon Poisoned Male Wistar Rats: Histopathological and Biochemical Evaluation', Egyptian Journal of Veterinary Sciences, 52(Issue The 9th International Conference of Veterinary Research Division National Research Centre, Giza, Egypt 27th -29th September 2021), pp. 35-40. doi: 10.21608/ejvs.2021.90194.1264
VANCOUVER
Hameed, A., Ahmed, J. The Neuro-protective Role of Vitamin B12 in Diazinon Poisoned Male Wistar Rats: Histopathological and Biochemical Evaluation. Egyptian Journal of Veterinary Sciences, 2021; 52(Issue The 9th International Conference of Veterinary Research Division National Research Centre, Giza, Egypt 27th -29th September 2021): 35-40. doi: 10.21608/ejvs.2021.90194.1264
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