Comparison of Hepatoprotective Activity of Cichorium Intybus and Cynara Scolymus Extracts Against Paracetamol Induced Hepatotoxicity in Broiler Chicken

Andalib, Fateme; Moosavian, Hamidreza; Khazraeinia, Parvaneh; Mohajerani, Sarvenaz; Pourakbari, Shima

doi:10.21608/ejvs.2021.48017.1200

Comparison of Hepatoprotective Activity of Cichorium Intybus and Cynara Scolymus Extracts Against Paracetamol Induced Hepatotoxicity in Broiler Chicken

Document Type : Original Article

Authors

¹ Research and Development unit of Barij Essence Pharmaceutical Company, Kashan, Iran.

² Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

10.21608/ejvs.2021.48017.1200

Abstract

This study focused on the effects of Cichorium intybus (Chicory), and Cynara scolymus (Artichoke) in reducing the hepatotoxicity effects of paracetamol in broiler chickens. Eighty four 21-d-old male commercial broilers were randomly allotted to 4 groups (n=21) and treated as follows for 2 weeks: Control group: basal diet alone, paracetamol group: similar to control group, in addition to intraperitoneal (IP) administration of paracetamol as 0.5 mg/kg of BW on 4th day. Cichorium intybus group: similar to paracetamol group and also daily oral administration of Cichorium intybus as 0.1 % ethanolic extract in drinking water, for 2 weeks. Cynara scolymus group: similar to paracetamol group and oral administration of Cynara scolymus as 0.1 % ethanolic extract in drinking water, for 2 weeks. The SGOT, SGPT, CPK, LDH, Uric acid, Creatinine and GGT serum levels were analyzed on 25th, 27th and 34th days of study. The mortality rates and body weight changes were measured in the end of study. Ethanolic extracts of Cichorium intybus and Cynara scolymu were found to decrease both the mortality rate and body weight loss. Also ethanolic extract of Cichorium intybus exhibited protective lowering effects of the serum enzyme levels, SGOT, GGT and CPK to a significant extent (P<0.05). In conclusion, the results showed the protective activity of Cichorium intybus and Cynara scolymus on paracetamol induced toxicity in broiler chickens. Based on the results in the present study, the ethanolic extract of Cichorium intybus showed significant better hepatoprotective effect as compare to Cynara scolymus.

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