Evaluation of the Anesthetic Action of Alfaxalone in Chicks and Compared with Alfaxalone/ketamine or Alfaxalone/xylazine.

Document Type : Original Article

Authors

1 Mosul - Iraq

2 Pharmacology and Toxicology Dept., Faculty of Veterinary medicine, University of Mosol

Abstract

Objective, alfaxalone is a neuro-steroidal anesthetic agent. The data on the anesthetic properties of alfaxalone in the birds is relatively inadequate. This article studies the anesthetic effect and efficiency of alfaxalone /ketamine or alfaxalone /xylazine anesthesia given in 7-10 day-old chicks. Methods, We used the up and down method to determine the median effective anesthetic dose of alfaxalone,  time to onset of anesthesia, duration of action, temperature, respiratory rate, and antagonize with flumazenil were evaluated.  Results, The median effective anesthetic dose (ED50) of alfaxalone was 32.88mg/kg . intraperitoneally. Alfaxalone at  25, 50, and 100 mg/kg induced anesthesia in chicks for (10 - 48 minutes). Flumazenil decreased the anesthetic period of alfaxalone. Alfaxalone at 50mg/kg causes bradypnea whereas at 100 mg/kg causes tachypnea. Alfaxalone produce hypothermia. The duration of anesthesia was significantly longer in alfaxalone/xylazine than in alfaxalone/ketamine but it causes more bradypnea. Conclusion, alfaxalone produces light surgical anesthesia so that it can be mixed with ketamine or xylazine for deep surgical anesthesia. Flumazenil may reverse the anesthetic effect of alfaxalone.

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History

  • Receive Date: 31 January 2021
  • Revise Date: 22 February 2021
  • Accept Date: 26 February 2021

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